Uptimes - any guidance?

[AG <computing.account@googlemail.com>]

Hello list

I'm running Squeeze on a desktop and so far have an uptime of some 11d.  
I am just curious whether or not there is any guidance/ advice on how 
long uptimes should be allowed to be run, or whether it is wise to shut 
down and reboot?

I'm thinking "wise" as from the perspective of the system and its 
overall functioning, etc.  By way of comparison, I have a headless 
OpenBSD box running nothing but firewall and router and it is a 
workhorse - just keeps on going and going.  I'm sure I have clocked 
uptimes of 90+ days on that without a problem.

Any thoughts on this?

Cheers

AG