"wine" command is a 32-bit ELF binary and "wine64" command is a 64-bit
ELF binary.
In my experience it doesn't matter which one to use, as long as you
run programs inside a prefix that supports both 32-bit and 64-bit
(WoW64). [1]
You can use just one prefix for both 32-bit and 64-bit programs, or
you can have as many prefixes as you want, each could be setup with
different settings and\or DLLs, tailored specifically for some program.
It is up to you how to manage them all.
I use "q4wine" program (it could be installed from Debian repo) that
helps to make some things easier.
There is also commercial software "CrossOver" [2] from the authors of
WINE project, but I've never used it.
[1] https://wiki.winehq.org/Wine_User%27s_Guide#WINEARCH
[2] https://www.codeweavers.com/crossover