Will somethings break if an administrator removes a file marked as conffile?

[Regid Ichira <regid23@yahoo.com>]

  Will the debian management system interpret a missing conffile as
though it was removed by the system administrator?  That is, will
somethings break if the administrator removes a conffile, rather 
then nullify its contents or commenting in each line of the file?
The file is marked by dpkg as a conffile.