Bug#835935: ITP: pirs -- Profile based Illumina pair-end Reads Simulator
Owner: Andreas Tille <firstname.lastname@example.org>
* Package name : pirs
Version : 2.0.2
Upstream Author : BGI
* URL : https://github.com/galaxy001/pirs
* License : BSD
Programming Lang: C++
Description : Profile based Illumina pair-end Reads Simulator
The program pIRS can be used for simulating Illumina PE reads, with a
series of characters generated by Illumina sequencing platform, such as
insert size distribution, sequencing error(substitution, insertion,
deletion), quality score and GC content-coverage bias.
The insert size follows a normal distribution, so users should set the
mean value and standard deviation. Usually the standard deviation is set
as 1/20 of the mean value. The normal distribution by Box-Muller method
The program simulates sequencing error, quality score and GC content-
coverage bias according to the empirical distribution profile. Some
default profiles counted from lots of real sequencing data are provided.
To simulate reads from diploid genome, users should simulate the diploid
genome sequence firstly by setting the ratio of heterozygosis SNP,
heterozygosis InDel and structure variation.