For most programmers, it is foolish currently develop in machine code, hexadecimal and assembly?

[françai s <romapera15@gmail.com>]

It is written in the introduction C - A programming language
Ansi standard written by Brian Kernighan and Dennis Ritchie:

For most programmers, the most important change is a
new syntax for declaring and defining functions.

For most programmers, it is foolish currently develop in
machine code, hexadecimal and assembly?

There are different opinions on this?