1. What difficulties (if any) might I expect in setting up the SATA drives?
   A quick search found quite a few posts where people had to mess with the
   BIOS, add a SATA driver, etc. with this motherboard.
 
2. If I buy a SATA 3 GB/s drive, will this motherboard only give me 150 MB/s
   anyway?  In that case maybe I should just go with ATA100 or ATA133.  I
   assume either would work.
 
Modern rotational devices don't even saturate ATA133, much less SATA-1, and nowhere near the "SATA II"/3Gbps capability. Fortunately, SATA II drives are backwards compatible.
Some SATA 3 GB/s drives have a jumper for it to operate in 150 MB/s mode; most WD drives do.  This along with enabling SATA support in your BIOS has worked for me.  But yes, the mobo will limit you to 150 MB/s (if you even reach speed that as Ron mentioned).  I have an old HP box that has SATA 150 support built into the mobo - no extra drivers needed, with XP or Debian.  Not sure if this applies to your mobo but you may not have any work to do if SATA 150 is supported natively.