Looking at the Fedora package, it is not currently built with Pipewire, so no way it will work on Fedora. But that is not Falkon's fault. We need to fix our QtWebEngine package.
It is the same for other affected distros.
That said, whether it will work then or hit other bugs, I cannot tell, since we have not enabled it yet.
In particular, I also do not know whether enabling that will not regress screen sharing under X11.