Re: Bug#680106: ITP: profisis -- Protein binding sites prediction (ISIS)
Hi,
this sounds like a pretty interesting target for the Debian Med team.
Would you consider joining the team and get support for sponsering and
technical help if needed?
Kind regards
Andreas.
On Tue, Jul 03, 2012 at 04:06:09PM +0000, cedric@gmx.ca wrote:
> Package: wnpp
> Severity: wishlist
> Owner: cedric@gmx.ca
>
>
> * Package name : profisis
> Version : 1.0.5
> Upstream Author :
> * URL : http://www.predictprotein.org/
> * License : GPL
> Programming Lang: Perl
> Description : Protein binding sites prediction (ISIS)
>
> Protein-protein interaction sites identified from sequence profisis (ISIS) is a machine learning-based method that identifies interacting residues from sequence alone. Although the method is developed using transient protein-protein interfaces from complexes of experimentally known 3D structures, it never explicitly uses 3D information. Instead, we combine predicted structural features with evolutionary information. The strongest predictions of the method reached over 90% accuracy in a cross-validation experiment. Our results suggest that despite the significant diversity in the nature of protein-protein interactions, they all share common basic principles and that these principles are identifiable from sequence alone.
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