Bug#530007: ITP: r-other-mott-happy -- GNU R package for fine-mapping complex diseases
Package: wnpp
Severity: wishlist
Owner: Steffen Moeller <steffen_moeller@gmx.de>
* Package name : r-other-mott-happy
Version : 2.1
Upstream Author : Richard Mott <Richard.Mott@well.ox.ac.uk>
* URL : http://www.well.ox.ac.uk/happy/happyR.shtml.
* License : GPL-2+
Programming Lang: C,R
Description : GNU R package for fine-mapping complex diseases
The idea behind this package is that when multiple strains of
animals that differ in their susceptibility to multiple diseases
are bread over multiple generations, then one can analyse the
contribution that a particular genetic locus has to each of those
diseases. While in the past this approach has been performed
for one disease at a time, this tool extends the statistics
for allowing multiple crosses and thus save animal lifes. A larger
stock of animals with more generations to keep them will further
help producing larger numbers of observable cross-over events
and thus help increasing the resolution of the mapping.
.
happy is an R interface into the HAPPY C package for fine-mapping
Quantitative Trait Loci (QTL) in Heterogenous Stocks (HS). An HS is
an advanced intercross between (usually eight) founder inbred strains
of mice. HS are suitable for fine-mapping QTL. The happy package is
an extension of the original C program happy; it uses the C code to
compute the probability of descent from each of the founders, at each
locus position, but the happy packager allows a much richer range of
models to be fit to the data.
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