Bug#283695: ITP: mssstest -- Normalisation of EDSS disease score of patients with Multiple Sclerosis
Package: wnpp
Severity: wishlist
* Package name : mssstest
Version : 2.0
Upstream Author : Shaun Seaman and Richard Roxburgh <Richard@Roxburgh.net.nz>
* URL : http://www-gene.cimr.cam.ac.uk/MSgenetics/GAMES/MSSS
* License : public domain but must not be sold -> non-free
Description : Normalisation of EDSS disease score of patients with Multiple Sclerosis
Suppose one is interested in determining whether the genotype at some
locus of interest affects the rate of progression of disease of people
with Multiple Sclerosis (MS). One method would be to calculate the mean
EDSS score in patients with each of the genotypes and test whether they
are significantly different. However, this approach is inefficient if
patients have their EDSS assessed at different durations of disease, as
patients who have had MS longer typically have higher EDSS scores
regardless of their genotype. By adjusting for duration, a more powerful
test can be developed.
MSSStest is a program for implementing the method described in the
article The Multiple Sclerosis Severity Score. R. Roxburgh S. Seaman et
al. (2004), accepted for publication by Neurology. It calculates MSSS
scores and uses these scores to test for differences between disease
progression rates in different groups defined by genotype at some locus.
A brief description of the method is given below.
The application of this predictor is technically not constrained to
Multiple Sclerosis which justifies the presentation as a Debian package.
I have created a package and hope for a sponsor - which is of course a
bit tricky for non-DFSG-compliant software.
Kind regards
Steffen
-- System Information:
Debian Release: 3.1
APT prefers unstable
APT policy: (500, 'unstable'), (500, 'testing')
Architecture: i386 (i686)
Kernel: Linux 2.4.20
Locale: LANG=C, LC_CTYPE=C
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