OT: Can lot of RAM can slow down a calculation workstation?

[Dan <ganchya@gmail.com>]

Hi,

I have a workstation Dell Precision T7610 that I use for scientific
calculations. It has two Xeon CPU E5-2650 v2 @ 2.60GHz with 64GB DDR3
1866MHz.

I would like to upgrade the machine and buy 256 GB of RAM. In the case
of a calculation that can fit in 64GB, Does too much RAM can slow down
the computer? I suppose that it shouldn't as long as the RAM is also
DDR3 1866MHz.

Thanks,
Dan